TMG (Trimethylglycine / Betaine) in Multivitamins
Trimethylglycine (TMG), also known as betaine anhydrous, is a methyl donor involved in homocysteine metabolism and the methylation cycle. It has been studied for cardiovascular health, liver function, and exercise performance.
Benefits
- ✓Donates methyl groups to reduce homocysteine (cardiovascular risk factor)
- ✓Supports liver health and fat metabolism
- ✓Has shown improvements in muscle strength, power, and endurance in RCTs
- ✓Works synergistically with choline and folate in the methylation cycle
- ✓May support healthy body composition
Recommended Daily Value
No official RDA; 500–2500mg/day used in clinical studies
Food Sources
- Beets (highest source)
- Spinach
- Quinoa
- Wheat germ
- Shellfish
Scientific Reference
Cholewa JM et al. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr. 2013;10:39.
Multivitamins Containing TMG (Trimethylglycine / Betaine)
The most evidence-based daily multivitamin on the market. Every one of its 26 ingredients is backed by human RCTs at the exact dose used in clinical trials — methylated B vitamins, glycinate-form minerals, 200mg hyaluronic acid for skin health, TMG for cognition and exercise, and microencapsulated carotenoids for eye protection. It deliberately excludes Vitamin A and E based on safety research, and consolidates 6–8 separate supplements into one formula.